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KMID : 0525720190240030165
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Journal of Chitin and Chitosan
2019 Volume.24 No. 3 p.165 ~ p.172
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Effects of Enzyme Hydrolysis Extract of Microalgae Residues on Collagen Synthesis and Matrix Metalloproteinase-1 Expression in UVB induced Human Dermal Fibroblasts
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Ha Sang-Keun
Kim Yoon-Sook
Park Yong-Kon
Lee Sang-Hoon
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Abstract
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In this study, we investigated anti-photoaging effects of enzyme hydrolysis extracts from microalgae by-products in UVB-induced human dermal fibroblasts (HDFs). After lipid extraction, three microalgal residues (Chlorella sp., Nannochloropsis sp., Phaeodactylum tricornutum) were enzymatically hydrolyzed by five commercial enzymes (α-chymotrypsin, Flavourzyme, Neutrase, Papain, Pepsin). Among the 15 enzymatic extracts, Flavourzyme extracts from Nannochloropsis sp. residues (FN) showed the highest inhibitory activities on UVB-induced expression of MMP-1 and significantly increased type I pro-collagen synthesis. The MAPKs/AP-1 signaling pathway was downregulated by FN in a dose-dependent manner. This study suggests that FN can be used as a therapeutic agent to prevent UVB-induced skin photoaging.
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KEYWORD
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Microalgae residue, Enzyme hydrolysis, Skin aging, MMP-1, Collagen synthesis
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